Ask HN: Career advice for a family member?

My uncle is in his 50's. He graduated with a B.S. in EE and went into sales, where he excelled. About 6 years ago he got laid off and has been struggling to find a job-- he can't even get interviews despite a stellar resume. He went through some health problems and what not but continues to apply to jobs. Despite the fact that he was at director level in his past jobs, he is open to entry level jobs in sales/marketing. What should he do?