Ask HN: How to work remotely for US company?

I've just signed on for a new role with a US company but I'm a resident in the UK and I'm not sure what the best way to handle wages is. I'll seek official tax advice in the UK, but in the meantime I'm hoping that HN has others in the same position.

The suggestion is that I set up as an independent contractor and work as self-employed, but I'm slightly concerned that it will flag up the "disguised employee" catch with IR35. It'd be great to hear from anyone with experience or advice here.