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How do you develop your Cython code? Do you use PyCharm? Did you start off from pure Python code? How easy is debugging and refactoring?

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I use SublimeText with a Cython highlighter; @redcrowbar uses Atom. I started coding uvloop & asyncpg directly in Cython, basically from scratch.

Debugging & refactoring are pretty much as easy as for pure Python code (which is a huge win over C). Sometimes when you're writing low-level code you can get a segfault, in which case lldb (or gdb) help you understand what's going on relatively quickly.

So do you use cygdb to debug Cython code or directly debug the generated C-API code?

I usually debug the generated C code directly (usually it's quite easy to understand the bug once you see where the program crashes.)

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