It really depends on your target audience.
For example, I make an app for hipster web devs, and it does really well on the Mac.
On the other hand, if you make an app for payroll accounting, I strongly recommend to make a Windows app.
Some apps, like a citation manager for researchers, really should be cross-platform and work on Linux too; a browser extension might work really great here.
If you'd like more specific advise, tell us more about the field you're interested in!
If you don't have an idea yet, I recommend looking for a niche first. Once you identified your target audience, you only need to find out what platform they use.