Two areas to highlight the point:
- High-energy anything. There's a saying that any propulsion system that could allow us to travel between planets in a reasonable (for human) timespan is also a weapon of mass destruction. And it's not just space travel - history of technology in general is about getting, storing and making use of bigger and bigger quantities of energy.
- Self-replicating system. The best-known example of these is also known as "biology". Something we're only beginning to play with on a serious level. Mishaps, or worse - deliberate malicious actors by crazy individuals - could have planet-wide consequences as our ability to manipulate biological nanomachines grows.
Sleep tight :).
(Also, alt-text from https://xkcd.com/728/ - "Maybe we're all gonna die, but we're gonna die in really cool ways.")
Humans, unfortunately, are very optimistic when it comes to workplace and household safety, while at the same time extremely resourceful when they need to make weapons out of mundane objects.
The most recent Expanse novel is an interesting take on how apocalyptic such an event could be http://amzn.to/2aD2AFl
If we get to that point, scaling up just consists of waiting a few decades of exponential growth to kick in. It might not even involve humans, but just letting automated robots continue to build more robots.
If the technology is there, moving mountains instead of ships is just a small jump.
The Iraq Iran war was filled with incalculable human tragedy and horror, of which both sides were perfectly willing to accept. Both the people who chained children together and forced them to charge machine gun nests and the people who mowed down children chained together from their machine gun nests.