Applied to careers, I take the talk as implying that trying things is the secret. After a certain level of experience in your career, you'll know whether you like it. Branching off of that, it might even be the right thing to do to find a new career.
One of the best pieces of advice I have ever received is "successful people do stuff. It doesn't matter what that stuff is, just do stuff and you'll eventually be successful". Some people will be luckier than others, and be successful at their stuff at a higher ratio, but overall, the ratio is about the same, and you just need to keep doing stuff.
Also, one of my favorite illustrations/cartoons of all time[2] speaks to this point. Basically, if you pursue the same career for your entire life, you're probably wasting your time. once you have your x,000 hours of work in, do something new where you can cross-apply that knowledge into domains that need it.
[1]https://youtu.be/l_F9jxsfGCw
[2]http://www.smbc-comics.com/?id=2722
Edit: sloppy link formatting