one of the interesting things in this video is that Facebook pretty much invented an equivalent of Flatpak/Zeroinstall/Click-packages to deploy their python apps.
Plus, the extent to which people can't do this because they have no/have a terrible build system is generally underestimated.
I've had great success using pex to bundle up tools that use a few dependencies. It's a lot simpler than tools that try to bundle a full python distribution.
Worked in production at a hundred different merchants
And PyInstaller is quite complicated.
That's certainly a practical strategy, but it reduces flexibility/modularity. Go-lang shares the same strategy for deployment. Perhaps it was inspired by Java-users.