Not sure what the answer is, but alcohol is involved in around 88,000 deaths in the US each year.
https://www.niaaa.nih.gov/alcohol-health/overview-alcohol-co...
Despite what the popular press says, Prohibition had some beneficial effects, and not all of the negative effects attributed to Prohibition actually arose out of Prohibition.
http://www.nytimes.com/1989/10/16/opinion/actually-prohibiti...