There have been many advantages to running on different platforms, which have various quirks.. different endians, page sizes, strict alignment requirements, stack-grows-up machines (hppa).
It also helps to have systems that are slow or have low memory, occasionally they hit bugs that are unnoticed on modern hardware.
Alpha may have been interesting in that it had some peripheral similarities to PC machines, but were actual 64-bit computers in the 90s. For kernel driver hackers, popping in a PCI network card that was probably never tested on anything besides a x86 PC, getting it to pass packets, and then making it your home firewall, was a thing of beauty.