I'm finishing a PhD at UC San Diego, and I've noticed a few things. First, there is a different dynamic for biotech talent. The biotech scene in SD is strong, and people seem drawn to that. Second, in contrast to LA at least, commuting in SD is not terribly difficult. And there is a light rail (trolley) beginning construction up to the UCSD campus from downtown. Third, this city is a draw for people (like me) who are looking for something less bustling than SF or LA, and I think it's important to try to keep young talent here by selling this idea. In biotech, we desperately need better software engineers.