There's something that tickles me about hooking up an SD card, a GigE network connection, a modern monitor, and modern USB keyboards and such... to a literal Commodore 64 to function as the CPU. I mean, "component mismatch" like the modern mismatch between RAM and CPU is one thing, and then there's "every peripheral in the system is orders of magnitude more powerful than my CPU".

(Yes, I am aware of how powerful the 1541 was.)

Did anything actually make any "sensible" use of that other than fast loaders? In any case the Turbo Chameleon cartridge I linked to above emulates the 1541 entirely including the 6502, so should allow for that in theory at least (though you won't be able to have the satisfaction of banging the drive head)

Because it's huge, heavier than the C64 (after all it contains a full 6502 computer and a big PSU and the drive mechanism), noisy, loses alignment easily, and is ridiculously slow.