I'm glad he's spending his money this way but how about the way he makes it. Facebook is not a particularly benign product and when you throw in the rising privacy, censorship, and "Free Basics" concerns, I would argue it's creeping towards having a net negative impact on the world.
I would have much more respect for Zuckerberg if he took a profit hit to fix his product and how his company interacts with the world. It's worth noting that Bill stepped away from Microsoft before he got deeply into philanthropy, in part to avoid conflict of interest. He knew he had a checkered past and he made a break with it. Zuck has a checkered present. Curing diseases in the developing world while pushing your product on it at the same time is somewhat morally ambiguous in my view.