Don't get me wrong, it's far better than IE, but whereas if you get something working in firefox, it usually works as is in safari/chrome, there's sometimes little quirks in Opera.
As a relatively small userbase use Opera, it'd just be nice if it did things exactly the same as firefox/Chrome - layout, scrolling, iframes, etc etc
I can't remember specific details, but I often notice weird layout quirks, or issues with scrolling (Not well defined in any standard).