The really great business opportunities are in the areas the Silicon Valley Kool-Aid drinkers don't even look twice. Many of them are not even fundable by VCs because they aren't sexy. YC funds some cool ideas, but most of them are immediately useful to the 20 year olds who come up with them, which means they are immediately taking on markets being built out by the rest of the startup community.
Ask a 60 year old manager of a sales force in a backward industry how his business works and you'll find real "organic" startup ideas. You might even find an idea that adds value to the universe, and might therefor yield revenue and profit.