The home-row hints are much better than the number hints that conkeror and vimperator give you. Although I did get really good at typing numbers, thanks to conkeror.
However, there are still too many small annoyances like not being able to open a new location in a new tab with a single command.
This means I can't just hit 't' and type a URL. A small nit-pick I know. I've just looked at the source, and it seems a problem with Google's API call (chrome.tabs.create). It is supposed to default to the New Tab page unless a URL is provided (and vimium does not provide a URL). On my install the home page is opened instead, so this is not Vimium's fault (and I'm very happy with it thus far).