DEC had a tool called VEST which was used to take native VAX binaries and convert them to run on Alpha AXP. It was very cool technology. A fair amount of the system utilities for OpenVMS on AXP were VESTed VAX binaries. I'm pretty sure the EDT editor was one of these.

The VEST technology could possibly be used to convert native VAX binaries to run on X86_64, I don't know for sure how the endian-ness would be dealt with.