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Wonder if this translates over to hormone replacement therapy in transgender people :\

Well women are generally much likelier to get dementias. Close to 2x the risk (as compared to males) too I think. A quick google search shows there's studies suggesting giving women testosterone could help with dementia.

That's a consequence of their increased empirical longevity.

It's plausible that this would negatively impact transgender women, considering dementia is associated with lower testosterone levels in men.

Please see: https://news.ycombinator.com/item?id=12708367

Disclaimer: IANAD.

That's not necessarily a relevant comparison since the goal of HRT in trans women is not simply to lower testosterone, but also to raise estrogen (and sometimes progesterone) to female levels.

Trans women on HRT are not hormonally like cis men (including men on ADT), so extrapolating any effect of sex hormone from cis men to trans women is going to lead you astray.

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