The past 100 years witnessed the rise of American domination of global business. Even if American business stays dominant, there's probably less growth from #1 -> #1 then there was during the rise to #1. And that's a big if.
In other words, the future returns of the S&P 500 is probably going to look more like the returns of a basket of international stock markets over the past 100 years than it will look like the returns of the S&P 500 over the past 100 years.
Many people believe that since the S&P 500 has never lost money over any 10 year period that it's never going to do so. It may be highly unlikely, but if you keep rolling those dice eventually you're going to come up snake eyes.