A Trump presidency would be an economic disaster: Objectively true because his policies involve reducing taxes, increasing spending, and isolating the country from free trade (eg. withdrawing from NAFTA which has been shown to have created jobs and growth on both sides of the border).
"American innovation would suffer": Because of economic consequences, so see above.
"He's erratic, abusive, and prone to fits of rage": I don't even know how you can argue against this, just watch one of his speeches.
"He represents a real threat to the safety of women, minorities, and immigrants": He personally is a threat to women, and his policies, such as they are, are now stiring up racial hatred. Again, an objective truth.
"Trump shows little respect for the Constitution": He announced several completely unconstitutional plans, such as suspending the right of US citizens to return to the country if they are Muslims. You don't need a ruling from the Supreme Court on this.