https://en.wikipedia.org/wiki/Simulator_sickness
No simulator can recreate the forces experienced in a real plane exactly, and it can be very disorienting and nauseating. As a simple example, consider a plane accelerating down the runway for takeoff --- that feeling of thrust that pushes you back into the seat can't be simulated. I have severe motion sickness and can't do things like play FPS, simulators, or watch videos with lots of movement in my field of vision without becoming very dizzy and fatigued. VR and 3D only makes it worse. Yet I have no problems driving or riding in a real plane.
To take it to the extreme, would you be willing to attempt landing a real 747 solo, having only ever flown using simulators?
Human brains are amazing things that, with no special effort - only practice and repetition - can combine a huge number of disparate inputs to synthesize the "feel" of something.
The airplane is a physical thing and it has "a feel". A good pilot (or jockey or surgeon or fighter or truck driver) has a tremendous amount of stored information and experience related to "the feel" of what they are doing. We would be vastly worse off (and less safe) if we discounted that human ability and fooled ourselves into believing that simulation can ever match the experience of doing a thing in the physical world.
[1] http://jalopnik.com/5629528/how-i-saved-a-747-from-crashing