I personally will mostly use it as a desktop replacement where I connect only one cable that goes to an UBS hub, monitor and will also charge the MacBook.

Mouse and Keyboard will be Bluetooth which I already use and that works well for me.

Regarding pendrives: I'll need to buy a new one, that sucks obviously, but I also have to say that I almost never used them although I bought an expensive one from Corsair just in case. In most cases I just used Google Drive to make that data available on all of my devices.