I've written my first LaTeX documents with LyX [1], a wonderful application, if you're just getting started.
I wrote my paper and master's thesis with a workflow involving LyX, LaTeX and python (scipy, numpy, mpl, doit for building the whole thing). The doit script ran the analysis pipeline, exported the figures, exported a .tex using the LyX CLI and ran all the latex/bibtex stuff to generate a PDF and and zip with all the necessary stuff for submission.
My colleagues looked at me weirdly (mech. engineering department), but I think it was worth it. Probably not time efficient, but at least for the peace of mind.