Base your business on it? No.

However I did put a Hackintosh into mission critical use for a bit. The machine was a ~$300 Dell Mini 9 which remains one of the all time easiest and most stable Hackintosh builds. To be fair it was a puny computer, but I upgraded mine with a larger SSD which made it pretty quick, and it was rock-solid stable. TBH I don't think it ever crashed or hang. And it was tiny.

I used this as my onstage computer for about a year running Reaktor and Sampletank. It took many falls. I never once had a problem with it. Its teensy size meant it could perch in a blank area on top of my keyboard.

However you're right about updates. They could be fatal and had to be well-researched and planned.