How about a web spec for creating sandboxed native UI? Would go nicely with WASM.
Hopefully WASM will fix the performance issue and the internet speed will get fast enough to compile and serve mature frameworks such Cocoa.
https://github.com/WebAssembly/design/blob/master/NonWeb.md
That doesn't mention HTML but focuses on avoiding JS entirely, so presumably there'd be some more direct way to invoke the program (but don't take my word for it ;) )