The end result of knowing a lot about a topic is often that you can't make very strong statements about it; they always end up being something like "you're kind of right because XYZ, but also kind of wrong because XYZ". So the ideal situation is more like "weak opinions, strong actions".
Let's take the example of where someone yells "Duck!". Most likely, you weren't paying attention and you have no clue why they would yell such a thing. There is a high chance that it's some kind of prank. But, I argue, you should still duck anyway, because the potential benefits (not getting a concussion) outweigh the risks (looking stupid).
Similarly, if you are running a startup, you should prepared to pivot at the first sign of customer mismatch, but meanwhile the majority of work will be in one direction, and you should work on it passionately.