Ok with the component of the managing partners being angels with experience in the whole sale process as a given in the equation, my number 2 recommendation would be to try to:
Not necessarily focus on emerging markets exclusively. You can build a global product, for a US+Euro market from Latin America. Example: Zoho is mostly built in India, Ustream is mostly built in Hungary, there is no good reason why there could not be a 37signals built in Guadalajara, or a Salesforce in La Paz, a good number of SaaS apps are not built in SV or the US.
Instead of doing an SMS system for Mexico, or a Yelp for Tampico, build a SaaS, that does not depend on Advertising, or multiple rounds of funding to earn revenues.
Finally, it helps to have some sort of Business Development in the U.S. in essence, a hybrid model.
I think funding those types of business models can provide the best outcome overall, because they can be very profitable without depending on round after round of financing from SV.