I'm a very experienced Front-End developer and a lot of the tooling questions still hit us in the ass. A few years ago we switched from a Backbone framework to React based with Reflux and Browserify. Within 6-8 months the mindshare switched to Redux and Webpack and now we're on to those. But its days to weeks to gain full understanding of those (Webpack is a slog) Unless your constantly keeping up to date every time you start a new project right now you're back to the drawing board on the current state of the React ecosystem.
I love React, I'm bullish on React-Native as well for a lot of use cases. I'll be happier once the community starts to lock in a bit better on a more consistent stack and I'm totally okay with their choice of Ember (curious on why this over Angular if they're doing a follow up ;-)