By the way before I get downvoted for my views, I am merely pointing out that actual conservatism is a position of Federalism rather than a position on a particular agendas of certain groups.
That means a government should be closer to the people it obsensibly represents and decision should be made at the lowest level until such time as it affects a higher level. For example, if California wants to legalize heroin, that's for California to decide -- it has no practical effect on people in Louisiana.
The problem with many social conservatives is that they are intellectually inconsistent -- you can't call for government to enforce what 'you' want but then call for smaller government when it comes to what 'they' want.
It's a question of the scope of government and at what level government ought to be acting -- it really isn't about specific issues but the bigger question of "Is this the role of the Federal government."
As a practical matter, saying that some issue is the proper domain of the states is equivalent to saying it can't be effectively regulated at all.
And it's not like the framers were unaware of that dynamic. They empowered the federal government to regulate interstate commerce precisely as a foil to the prohibition on states to do so.
Citizens don't really have the freedom to choose on issues like that unless they have the freedom to close their markets to people who do not play along. The Constitution takes away that freedom.
Florida isn't giving money to anyone [3].
[1]: https://en.wikipedia.org/wiki/Aristotle
[2]: https://en.wikipedia.org/wiki/World_population#Past_populati...
[3]: http://www.theatlantic.com/business/archive/2014/05/which-st...
People underestimate the side effects of state-level or city-level legislation. Due to the size of the California economy the laws in California absolutely have practical effects on people in Louisiana. This is why national and international laws and agreements matter.
For example, environmental regulations on automobiles (this interview transcript is obviously one example and needs to be evaluated in the context of alternative information, but I think it's adequate to demonstrate the point that interactions between states are significant to a degree that dismissing them is risky): http://e360.yale.edu/feature/californias_clean_car_rules_hel...