According to https://en.wikipedia.org/wiki/Instructions_per_second , a modern i7 processor handles north of 100,000 MIPS.
According to https://en.wikipedia.org/wiki/Transistor_count, the 6502 had 3510 transistors.
At 100,000 MIPS, a modern CPU would have a budget of ~56k instructions to process one cycle of that CPU, or about 16 instructions per transistor.
So it would seem it might now be possible to simulate those old processors, at the transistor level, in real time. Is anyone aware of experiments in this domain? If not really useful, that sounds like an interesting fun (side) project.