Depends on what you count as "big". If you look at languages used on github, for example:
Clojure is doing OK (better than Common Lisp), but not great (worse than Haskell and Emacs lisp).
Clojure is doing OK (better than Common Lisp), but not great (worse than Haskell and Emacs lisp).
That's a really nice web site. It took me a moment to realize it's showing quarterly data (sadly last updated in 2014), and that the ranking is based on the first metric ("number of active repositories").