https://youtu.be/VBbejeKHrjg?t=9m22s
ING, USA Today, IBM, General Electric, Comcast, Net-A-Porter, BBVA, Coca-Cola, Electronic Arts - one of the biggest players in their industries.
And back then when I was trying it out there wasn't any easy way to integrate webpack (or something like it) which made it difficult as I've gotten very used to a good bundler/compiler.
As you said, you kinda just have to expect a little pain pre-1.0. But the time investment in learning and using it has been worth it in my opinion.
The support graph is starting to look a lot better, though: https://jonrimmer.github.io/are-we-componentized-yet/
Safari has shipped 2/4 of them already with the Custom Elements v1 spec currently in the Safari Tech Preview and turned on by default. https://webkit.org/blog/7027/introducing-custom-elements/