As we shift to virtual keyboards, there is again a benefit to having distance between frequently-used keys. Predictive typing guesses are better when keys like A, E, and I are not close to each other, since there are many words where only the vowel differs (bit/bet/bat, nit/net/nat, etc.).
On a somewhat related note, I've been trying Swype recently. After a couple weeks, I'm still not more efficient than regular typing, but I could see how I might get there eventually. I'd be curious to know what others have found the learning curve to be—how long it takes to "break even" and whether efficiency continues to improve for months.