The short answer to your question is that the impact of everything viable that is not SENS is probably going to be about the same as exercise or calorie restriction in your life span if you are in the middle of life now. Which is to say +10 years if you pick the right things, and the people building those things do a good job. That would be, say, the combination of a couple of successes in things building upon mTOR or stem cell or telomerase therapies or etc. Not resveratrol, not 99% of the other pharmaceuticals, not 99% of the possible gene therapies, and not 99% of what people are trying to sell you.