1. If laws aren't immutable, then either some function governs their changes over time, which makes them immutable when you consider that function, or the laws are entirely random, in which case all science is impossible anyway, and so we shouldn't concern ourselves with this case.
2. The difference is that there is evidence of a multiverse in quantum mechanics, the most well-tested scientific theory of all time. The Many-Worlds interpretation is the most reasonable explanation of QM phenomena.