Interesting. I was poking around the MAME database and found that the Z80 was used as recently as 2010 by a company called Igrosoft to make video slot machines, along with some modern PLDs and support chips. They also use a YM2149-compatible sound chip for that authentic bleepy sound.
More details: https://github.com/mamedev/mame/blob/master/src/mame/drivers...