You mean intrusive like the AMP header on every !@$! mobile page now that's not only annoying but breaks the standard UX?
"Would you like to search and browse the mobile web through Google? Only if you disable your ad blocker."
I'd be shocked if they don't try to force AMP on the desktop as well next if this works out for them.
So if someone decides AMP pages should be blocked, your ad blocker will start blocking them.
It's actually one of the reasons I stopped using them. The idea of some person somewhere deciding what I see and don't see didn't quite jive with me. And it was impacting me by blocking things like Google shopping which I was trying to use.
I also never really liked the idea of blocking ads, depriving content creators of money, and I don't want to always pay for everything with money.
That, combined with the lack of easy control, opinionated ad blocking utilities (stop blocking webRTC dammit. I know you think it's a problem, I don't), general breakage across the web, performance issues with most blockers, and more made me stop using them.
Too bad AMP won't work with it, but there's no way I'm disabling it as life before content blockers on iOS was hell. (Sites hijacking you to the app store, etc.)