These "de novo" mutations can sometimes affect or "break" genes important for normal development, thus resulting in autism. They can be studied by sequencing father/mother/child families and comparing the genetic sequence of each. The de novo mutations show up in the child only. We can differentiate if they arose in the father's sperm or the mother's eggs by examining the "haplotype" around each of these mutations (basically, looking for other nearby mutations that were inherited by the child from either mom or dad).
For more on this, see this paper: https://www.ncbi.nlm.nih.gov/pubmed/22495309
[0]: https://en.wikipedia.org/wiki/Spermatogenesis#/media/File:Sp...
Maybe autistic potential fathers find more acceptance in today's nerd culture, and have the opportunity to pass on autistic genes :)
Early studies showed autism as 90% generic, but more recent ones put it much lower.