No route to permanent residency via the TN visa. With the status of NAFTA up in the air now that Trump's in power, that's potentially a pretty big deal.
There's no real route, no, but you can take the EB Green Card path. You just can't leave the country from the period starting when you file for adjustment of status and ending when you get EAD/AP (otherwise you're never coming back in under TN status again and will likely get banned for a few years :P)