I've lost my personal home dir twice in my life:

1993 I tar.gz'd it as I was leaving college and ftp'd that file NOT in binary mode; didn't discover it until too late.

1995, I blew away the mount point for my NFS server with all my home dir and data but had left the server mounted (and was running as root, no root squash, etc)

At work, training a new operator, I had them run the script that shutdown all web servers rather than regenerating the CMS caches on them. As the alerts rolled in, I reassured him that we'd done the right thing. Many minutes later, we looked at the logs and saw "webservers-shutdown-all" instead of "webservers-regen-all"