Name: Youtube Keyword: y URL: http://www.youtube.com/results?search_query=%s
Then just type "y civilization v" and shazam, you're on Youtube, looking at a list of trailers and previews for Civilization V.
Firefox has the same feature; I believe it's called "Keyword Search" and can be accessed through Bookmark Manager. I always found Firefox's separate search box redundant for this reason.
I actually use both. I've about 20 keywords - I use the search box when I think I'll need to search across multiple engines (though I usually copy paste the words, I guess I use them as a short scratch pad) and use keywords when I expect I won't have to re-enter the search elsewhere.
And for the keystroke-obsessed, Ctrl+K clears the location bar and puts in the question mark for you. :)
youtu+TAB and then enter your keyword. Works with every site that support opensearch. en.wiki+TAB will search wikipedia etc.