The void-home is a coping mechanism individuals use to mute their internal disappointment of unfulfilled aspirations embedded in world-view & the vanishing of environmental low-hanging fruit & the consternation brewing according to the matter which makes up their body.
If you are confident in having learned that humanity means kindness, virtue, ubuntu, you may begin to experience symptoms of satisfaction, comfort, optimism, interesting challenges, self-realization and a steady flow of rewards.
The opposite absorbable world lesson the cruelest kind of learned helplessness. Look what fear has done to my body [0]. You might see humanity as fundamentally anti-human, kindness as ironic, nihilism as the stablest philosophy, even if you understand that, logically, the conclusion of nihilism is bound to invalidate the conclusion of nihilism itself.
Folks often invoke "curiosity killed the cat" as a way to communicate "unenriched and empowerment-lacking people are prone to self-annihilation while in their search for harmony". What they don't do is follow the thinking to its conclusion: "But the cat was simply trying to gain root access beyond a seemingly impenetrable social inertia. The cat knew that the subjectivity of contribution to the outcomes of local events was far more rewarding than the dissonance of a depressive hedonism trap.
It's always unexpected - if you could expect you would always appropriately manage your negative expectations, you would call such periods of discontent "vacations."
Like a situation where you're trapped in an action-selection fixed-point of free-energy-dissipation-minimization.
Like a phantom limb, you realize that the psychic model/hierarchical system of values/your world-view ultrafilter/your "rosebud" you placed faith into, you begin to realize that the abstraction might not really have captured every partial ordering/relation/utopia you could have benefited from knowing sooner.