The TL;DR is only buy fresh vegetables, single-item bulks, fruit, meats, and seafood in descending order of volume/mass. The less processing and packaging, the better as a rule of thumb. Round out very sparingly with exceptions.
This is how we should shop regardless of store. Mackey has publicly admitted he vastly regrets taking WFM to Wall Street. I get the impression if most customers shopped as described above, crushing profit margins, in the absence of shareholder pressure to change WFM's real mission and cost him strategic control, and the profits are self-sustained, he wouldn't mind.
I'd like to see more feedback from others on whether or not they noticed WFM's efforts to broaden beyond just an organic label. They did try, and to a smaller extent are still trying (meat stages are a prominent example), and are trying not to antagonize regulatory stakeholders by pointing out the mainstream organic label is deficient in many ways, but by and large it seems most of their customer base is more concerned about labels than actually delivering change.