Or about 670 BFRs [1].
It would take 6 cycles of tripling size and/or performance to get a single system with enough thrust to meet your 7/42 year schedule. The Saturn V first flew in 1967 [1]; SpaceX plans to launch its Interplanetary Transport System (ITS) in 2022 or 2024 [2]. That's an expected 60 years to triple performance.
[1] http://waitbutwhy.com/2016/09/spacexs-big-fking-rocket-the-f...
[2] https://en.wikipedia.org/wiki/Saturn_V
[3] https://en.wikipedia.org/wiki/Interplanetary_Transport_Syste...