I'd love to see some sort of bootstrapped version that makes use of .NET Native or CoreRT or whatever they use today, and I'd REALLY like to see a strong Stdlib for F# that takes into account what functional programmers are used to.
I've been doing functional programming for several years, and I feel like a moron working with F# because I don't know half of these dumb .NET classes and some of the domain problems don't really leave me able to budget enough time to bootstrap my own solutions OR learn all the .NET stuff I need. Especially not when I can jump into several other languages and have a working prototype often in days or hours.