Humanity will have to figure something out here. Our bodies are evolved for hunting / gathering, yet over a few thousand years we've evolved to sitting in an office chair all day. Until our bodies have adapted to what, we need to come up with a way to simulate the environment we are actually optimized for.
That environment is still out there.
Treadmill. VR headset or at least a wall-projector. Nature soundtrack. Variable speed fan with heating, cooling, and automatic scent generator.