You're essentially asking about the difference between active and passive existential nihilism. Or in non-philosophical terms, asking who is resigned to their existence and who actively searches to find meaning in it.

Active nihilism is much more beneficial and relates to stoicism. It holds that you must find your meaning, which is really what everyone does anyway, whether through a super natural being or friends, family, or one's life work (read Man's Search for Meaning by Victor Frankl. The best book I've ever read that relates these ideas as a holocust survivor).