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This is my question as well. I've seen plenty of advice about how Python is a bad choice for any crypto application because it's almost impossible to secure Python's memory. Is JS different somehow?

I can't answer your questions with certainty, but for those who can, could ES6 WeakMap address these two things?

WeakMap just allows you to tell the GC "don't hold on to this memory just because I'm using it as a key in this Map" -- it doesn't let you tell the GC what to actually do with the memory.

Couldn't buffers be used for explicit memory control? I think that was how emscripten implemented memory management