FWIW, I was very explicit with investors that we would never flip the company. Our intention is to build a company that will last forever. I also acknowledged that things change. If Denny and my opinion changed would let our investors know right away. So far it hasn't changed. If you are planning on partnering with an investor make sure they understand your values and your intention. To clarify this I put it in writing in an email and have the person confirm they understand.
I always make myself available to chat about this with scientists. Drop me a line by email.
Stay crazy.