Er, the context of this subthread is about people who already do experiment on themselves. People in the "nootropics community." There are a lot of them.

You could try teaching these individuals experimental protocols if you like, but if you enforce them, that means you're the experimenter. You're not allowed to be the experimenter. You just have to hope they're doing something useful. Probably you'd point a lot of automated instrumentation at each room, rather than having any human observers giving anyone (costly) individual attention, because most of the experiments would be too mired in sources of error to tell you much.

But keep in mind that the point wouldn't be to capture subtle things like drug efficacy. The point would be to find out about side-effects that might otherwise not be found, by having people around when they suffer adverse reactions to the drug to help the person not-die, and then being able to pull reports directly from the people who helped the person not-die, to find out (in clear medical terms) what the adverse reaction was.