Ask HN: How to infer website quality from HN data?
Sentiment analysis, front page appearance to total submission ratio just to name few ideas.
Another option would be to check how many different people are posting links to a site. Each person could be given a quality rating based on how many points they have and how many other sites they post from.
Someone who posts only the same site and has low points (and low comments) is probably just the site's owner, for example.